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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CBL All Species: 12.73
Human Site: S524 Identified Species: 25.45
UniProt: P22681 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22681 NP_005179.2 906 99633 S524 G T A S K A A S G S L H K D K
Chimpanzee Pan troglodytes XP_508878 860 94390 S480 A S K A A S G S L H K D K P L
Rhesus Macaque Macaca mulatta XP_001104812 907 99834 S525 G T A S K A A S G S L H K D K
Dog Lupus familis XP_546487 769 85337 T408 R N Q N P D L T G L C E P T P
Cat Felis silvestris
Mouse Mus musculus P22682 913 100531 S522 G T A S K A A S G S L H K D K
Rat Rattus norvegicus Q8K4S7 938 104634 P534 T G S P K S S P C M V R K Q D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520299 576 65568 W215 F T R L F Q P W S S L L R N W
Chicken Gallus gallus NP_989539 903 99806 P508 S T S S K A A P G T L H K D K
Frog Xenopus laevis Q6GQL0 918 102813 P544 T G S P K S S P C M V R K Q D
Zebra Danio Brachydanio rerio NP_001007331 913 101156 A512 S P G A T S K A P S H H K D K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648224 878 94769 S510 P T L S L P S S S C S S I A A
Honey Bee Apis mellifera XP_395448 739 83094 V378 C A E N D K D V R I E P C G H
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 98.9 70 N.A. 92.7 49.5 N.A. 52.3 84 49.6 72.2 N.A. 41.6 44.5 N.A. N.A.
Protein Similarity: 100 94.9 99.2 72 N.A. 95 60.8 N.A. 57.6 89.4 59 80.2 N.A. 53.6 56.9 N.A. N.A.
P-Site Identity: 100 13.3 100 6.6 N.A. 100 13.3 N.A. 20 73.3 13.3 33.3 N.A. 20 0 N.A. N.A.
P-Site Similarity: 100 33.3 100 20 N.A. 100 40 N.A. 33.3 86.6 40 53.3 N.A. 26.6 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 25 17 9 34 34 9 0 0 0 0 0 9 9 % A
% Cys: 9 0 0 0 0 0 0 0 17 9 9 0 9 0 0 % C
% Asp: 0 0 0 0 9 9 9 0 0 0 0 9 0 42 17 % D
% Glu: 0 0 9 0 0 0 0 0 0 0 9 9 0 0 0 % E
% Phe: 9 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 25 17 9 0 0 0 9 0 42 0 0 0 0 9 0 % G
% His: 0 0 0 0 0 0 0 0 0 9 9 42 0 0 9 % H
% Ile: 0 0 0 0 0 0 0 0 0 9 0 0 9 0 0 % I
% Lys: 0 0 9 0 50 9 9 0 0 0 9 0 67 0 42 % K
% Leu: 0 0 9 9 9 0 9 0 9 9 42 9 0 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 17 0 0 0 0 0 % M
% Asn: 0 9 0 17 0 0 0 0 0 0 0 0 0 9 0 % N
% Pro: 9 9 0 17 9 9 9 25 9 0 0 9 9 9 9 % P
% Gln: 0 0 9 0 0 9 0 0 0 0 0 0 0 17 0 % Q
% Arg: 9 0 9 0 0 0 0 0 9 0 0 17 9 0 0 % R
% Ser: 17 9 25 42 0 34 25 42 17 42 9 9 0 0 0 % S
% Thr: 17 50 0 0 9 0 0 9 0 9 0 0 0 9 0 % T
% Val: 0 0 0 0 0 0 0 9 0 0 17 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 9 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _